UTERINE LEIOMYOMA is the most common benign tumor of genital tract. The etiology of myomas is unknown. LEIOMYOMA shows a broad spectrum of radiographic appearances depending on the number, size, and location of the tumor. The diagnostic method for UTERINE LEIOMYOMAs is based primarily on the clinical situation. Despite of the varied diagnostic options such as; transvaginal sonography, sonohysterography, hysteroscopy, laparoscopy and MRI; hysterosalpingography is still one of the valuable imaging methods for identification of UTERINE LEIOMYOMA.The various features of the proved LEIOMYOMA are illustrated in this pictorial review. The incidence, risk factors and clinical features will also be discussed briefly

Presacral tumors are a rare group of tumors located posterior to the rectum in the retrorectal or presacral space. Due to the lack of specific symptoms and difficult anatomic localization, they present a diagnostic and management challenge for the surgeons. We present a case of retrorectal schwannoma in a young female who was initially misdiagnosed as a UTERINE fibroid on ultrasound and taken up for myomectomy. The tumor was later successfully excised by a combined abdominosacral approach. The clinical features and management of presacral tumors are discussed in this article.

Background: Although LEIOMYOMAs are the most common gynecologic disorders, non-puerperal UTERINE inversion due to LEIOMYOMA is considered as a rare clinical problem. This condition can occur as a complication of a large sub-mucous LEIOMYOMA that leads to dilate cervix and protrude into vagina. The patient may have several symptoms such as heavy vaginal bleeding, pelvic pain and intermittent acute urinary retention.Case: We presented a 32-year-old nulliparous woman with 17 years of unexplained infertility and diagnosis of a large vaginal prolapsed non-pedunculated LEIOMYOMA.Conclusion: Haultain’s procedure was used to reposition UTERINE inversion and remove LEIOMYOMA through a posterior incision, using laparotomy.

Background: UTERINE LEIOMYOMA, also called fibroid, is a benign tumor that arises due to monoclonal transformation of myometrium, the smooth muscle cell layer of the uterus. Fibroids cause several complications including infertility, miscarriage, bleeding, pain, and dysmenorrhea. Recent studies have revealed the role of mutations in MED12 gene exon 2 in various populations; however, the reported frequency of these mutations differs between reports. In addition, it is suggested that mutations in exon 1 may also play a role in LEIOMYOMA. The aim of the present study was to screen for MED12 exon 1 mutations in LEIOMYOMA tissue samples of Iranian patients. . Methods: We performed mutational analysis of exon 1 and the flanking intronic regions using multitemperature single-strand conformational polymorphism (MSSCP) and sequencing analyses in 120 UTERINE LEIOMYOMA samples. Results: No mutations were detected in exon 1 of MED12 in our samples. Conclusions: According to the literature and the present results, mutations in the MED12 exon 1 are rare. However, we could not ignore the role of these mutations in developing LEIOMYOMA.

Background and Objective: For nearly a century, it has been suspected that reproductive tract infections play an etiologic role in UTERINE LEIOMYOMA. However, no epidemiologic study of LEIOMYOMA has used the polymerase chain reaction (PCR) to compare UTERINE tissues from cases and non-cases, and to investigate associations between UTERINE LEIOMYOMA and infections detected by PCR. Methods: In this case-control study, 92 LEIOMYOMA tissues from cases, and 94 myometrial tissue from controls were screened by PCR for cytomegalovirus, Chlamydia trachomatis, herpes simplex virus-1, 2, and human papillomavirus typed as 16/18 or another strain. Multivariable analysis used age-adjusted logistic regression, and generalized linear regression as appropriate. Results: In the UTERINE tissues of cases and unmatched controls, the prevalence of infection was: cytomegalovirus (32. 6%, 7. 4%), C. trachomatis (23. 9%, 37. 2%), herpes simplex virus-1, 2 (25. 0%, 13. 8%), human papillomavirus 16/18 (13. 0%, 10. 5%). LEIOMYOMA was associated with cytomegalovirus (Odds Ratio (O. R. ) 6. 10; 95% confidence interval (C. I. ), 2. 40, 15. 55) and Chlamydia (O. R. 0. 47; 95% C. I. 0. 23, 0. 97). Likewise, the log count of LEIOMYOMA was higher with cytomegalovirus (+0. 65, 95% C. I. +0. 34, +0. 95) and lower with Chlamydia (-0. 71, 95% C. I.-1. 12,-0. 29). Conclusion: This first application of PCR to LEIOMYOMAta and control UTERINE tissues from non-cases reveals that cytomegalovirus is associated with the presence, number, and volume of UTERINE LEIOMYOMA, while C. trachomatis is inversely associated with LEIOMYOMA, but only in the absence of cytomegalovirus. Current findings provide preliminary evidence that common reproductive tract infections contribute to the growth and control of at least some cases of UTERINE LEIOMYOMA.